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Chemotherapy was potentiated by E7449 and single agent experienced major antitumor action in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell traces, likely by way of TNKS inhibition. In step with this likelihood, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilizat